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Abstract

Molecular Biology In Young Women With Breast Cancer: From Tumor Gene Expression To Dna Mutations

VOLUME 69 - NUMBER 4 / July-August (In-depth Reviews)  doi: 10.24875/RIC.17002225

Liliana Gómez-Flores-Ramos, Instituto de Investigaciones Biomédicas; Unidad de Investigación Biomédica en Cáncer. Universidad Nacional Autónoma de México; Unidad de Epidemiología, Instituto Nacional de Cancerología. Mexico City, Mexico
Andrea Castro-Sanchez, Joven & Fuerte: Program for the Care and Research of Young Women with Breast Cancer in Mexico, Mexico City, Mexico
Omar Peña-Curiel, Breast Cancer Center, Hospital Zambrano Hellion, Tecnológico de Monterrey, San Pedro Garza García, Monterrey, N.L., Mexico
Alejandro Mohar, Department of Research and Breast Tumors, Instituto Nacional de Cancerología (INCan), Mexico City;; Joven & Fuerte: Program for the Care and Research of Young Women with Breast Cancer in Mexico, Mexico City; Unidad de Epidemiología e Investigación Biomédica en Cáncer, INCan-UNAM, Mexico City; Mexico

Young women with breast cancer (YWBC) represent roughly 15% of breast cancer (BC) cases in Latin America and other developing regions. Breast tumors occurring at an early age are more aggressive and have an overall worse prognosis compared to breast tumors in postmenopausal women. The expression of relevant proliferation biomarkers such as endocrine receptors and human epidermal growth factor receptor 2 appears to be unique in YWBC. Moreover, histopathological, molecular, genetic, and genomic studies have shown that YWBC exhibit a higher frequency of aggressive subtypes, differential tumor gene expression, increased genetic susceptibility, and specific genomic signatures, compared to older women with BC. This article reviews the current knowledge on tumor biology and genomic signatures in YWBC.

Keywords: Breast cancer. Young women. Molecular biology. Hereditary breast cancer.

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