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ABSTRACT

Histology as Prognostic Factor in Early-Stage Cervical Carcinoma. Experience in a Third-Level Institution

VOLUME 69 - NUMBER 5 / September - October (Original Article)  doi: 10.24875/RIC.17002143

Salim A. Barquet-Muñoz, Department of Breast Cancer Surgery, Instituto Nacional de Cancerología, Mexico City, México
Efraín Cruz-Rodríguez, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
David Cantú-de-León, Clinical Research, Instituto Nacional de Cancerología, Mexico City, México
David Isla-Ortiz, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
Gonzalo Montalvo-Esquivel, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
Luis Alonso Herrera-Montalvo, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
Carlos Pérez-Plasencia, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
Delia Pérez-Montiel, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
Ángel Herrera-Gómez, Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico

Background: Cervical carcinoma (CC) is one of the most frequent neoplasms, especially in developing countries. The most common
histopathological type is squamous cell carcinoma (SCC), followed by adenocarcinoma (AC) and adenosquamous carcinoma
(ASC). Prognosis according to histological type is controversial. Objective: The objective of this study is to describe and compare
the prognoses of the most common histologies of CC in the early stages. Materials and Methods: We reviewed records of patients
attended at the Instituto Nacional de Cancerología of Mexico with CC surgically treated Stages IA2-IB1 and IIA1, including the
histological types SCC, AC, and ASC. Patients who had another malignant neoplasm, cervical cancer in situ, locally advanced
neoplasm, and metastatic neoplasm were excluded from the study. A descriptive and comparative analysis was conducted. Overall
survival (OS) and disease-free period were calculated for each histological type with the Kaplan–Meier method and were compared
with the log-rank test. Results: A total of 202 records were obtained, of which 131 (64.9%) had SCC, 57 (28.2%) AC, and
14 (6.9%) ASC. The 5-year DFS was 94.4% for SCC, 98.1% for AC, and 92.3% for ASC, without a statistically significant difference
(p = 0.55). The 5-year OS for SCC was 97.9%, for AC was 97.8%, and for ASC was 100%, without a statistically significant
difference (p = 0.702). Conclusions: DFS and OS did not differ between the most common histological types of CC at the early
stages.

Keywords: Cervical carcinoma. Squamous cell carcinoma. Adenocarcinoma. Adenosquamous carcinoma.

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