ISSN: 0034-8376
eISSN: 2564-8896
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Abstract

Mexican Human Leukocyte Antigen Alleles Might Predict Clinical Outcome in SARS-CoV-2 Infected Patients

VOLUME - NUMBER / (Forthcoming Articles)

Rafael Garcia-Silva, Immunogenetics Division, Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Susana Hernandez-Dono, Immunogenetics Division, Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Lourdes Mena, Immunogenetics Division, Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Julio Granados, Immunogenetics Division, Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Country border lines are illusory and do not restrain the spread of pathogens. For instance, the US has now become the epicenter of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, but just South of its border, in Mexico, confirmed cases have only surpassed a thousand patients, and fatalities are less than a hundred. Such drastic differences replicate worldwide, with no merit due to health-care policies, but probably to ancestry and genetics. Human leukocyte antigen (HLA) genes dictate the immune response to pathogens. Interestingly, HLA genes are the most polymorphic in the human genome and are non-randomly inherited as conserved blocks. The distribution of HLA alleles is determined by ancestry and natural selection through infectious diseases.

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