ISSN: 0034-8376
eISSN: 2564-8896






Updating Zika Diagnostic Methods: The Point-of-Care Approach



Mirna Burciaga-Flores, Medical and Pharmaceutical Biotechnology Unit, Center for Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara, Jal., México
Marissa Reyes-Galeana, Medical and Pharmaceutical Biotechnology Unit, Center for Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara, Jal., México
Tanya A. Camacho-Villegas, Consejo Nacional de Ciencia y Tecnología (CONACyT) - Medical and Pharmaceutical Biotechnology Unit, Centro de Investigación y Asistencia y Diseño del Estado de Jalisco (CIATEJ), Guadalajara, Jal., Mexico
Abel Gutiérrez-Ortega, Medical and Pharmaceutical Biotechnology Unit, Center for Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara, Jal., Mexico
Darwin E. Elizondo-Quiroga, Medical and Pharmaceutical Biotechnology Unit, Center for Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara, Jal., Mexico


Zika virus (ZIKV) has gained great importance worldwide since the past epidemic that occurred in 2015 in Brazil. Early identification of ZIKV is critical to minimize transmission and prevents potentially devastating consequences, including microcephaly in neonates of infected women, congenital blindness, or Guillain-Barré Syndrome. However, this is not an easy task, considering that approximately 80% of ZIKV infection cases are asymptomatic or oligosymptomatic, there are diverse modes of transmission (vertical transmission is through vectors and horizontal transmission through blood, saliva, semen, and urine from infected people), and the fact that ZIKV has a high identity percentage with other cocirculating Flaviviruses such as dengue. Here, we review ZIKV diagnostic methods, with special emphasis on the development of point-of-care diagnostic assays, since these devices commonly have two important advantages: they provide prompt screening and are affordable.



Keywords: Zika. Diagnostics. Flavivirus. Point-of-care.