ISSN: 0034-8376
eISSN: 2564-8896
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Abstract

Immunology of Cervical Cancer

VOLUME - NUMBER / (Forthcoming Articles)

Joaquín Manzo-Merino, Department of Basic Research, Instituto Nacional de Cancerología, Mexico City; Consejo Nacional de Ciencia y Tecnología (CONACyT)-Instituto Nacional de Cancerología, Mexico City; Mexico
Susana del-Toro-Arreola, Department of Physiology, University Center for Health Sciences, Universidad de Guadalajara, Guadalajara, Jal,; Mexico
Leticia Rocha-Zavaleta, Department of Molecular Biology and Biotechnology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Óscar Peralta-Zaragoza, Infectious Diseases Research Center, Instituto Nacional de Salud Pública, Cuernavaca, Mor., Mexico
Roberto Jiménez-Lima, dad Nacional Autónoma de México, Mexico City, Mexico
Vicente Madrid-Marina, Infectious Diseases Research Center, Instituto Nacional de Salud Pública, Cuernavaca, Mor., Mexico

Optimal function of the immune system allows the recognition and elimination of infected and tumor cells. However, these cells can develop mechanisms to evade the cellular immune response. In human papillomavirus (HPV) infection, dysregulation of major histocompatibility complex Class I molecules and other components of the innate immune system promote the survival of infected cells by allowing the infection to persist which, in turn, favors the development of cancer. Further, tumor cells possess inherent mechanisms designed to block the recognition and activation of cytotoxic lymphocytes: particularly, HPV proteins such as E1 and E2 and oncoproteins E5, E6, and E7 that inhibit immune mechanisms and/or stimulate the expression of immunosuppressive cytokines. These mechanisms include a decrease in receptor activation and costimulating molecules on the surface of immune cells, as well as the constitutive expression of molecules that inhibit their function, which allow HPV persistence and tumor progression. Immunotherapy-based therapeutic options are positioned as excellent candidates for the treatment of cervical cancer.

Keywords: Cervical cancer. Human papillomavirus. Cytotoxic T lymphocyte-associated protein 4. Programmed death protein-1. Programmed death ligand-1. Activation.

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