ISSN: 0034-8376
eISSN: 2564-8896
< Back

Abstract

Immunonutrition in Cervical Cancer: Immune Response Modulation by Diet

VOLUME - NUMBER / (Forthcoming Articles)

Oscar Medina-Contreras, Epidemiology, Endocrinology & Nutrition Research Unit, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Julissa Luvián-Morales, Department of Clinical Research, Instituto Nacional de Cancerología (INCan); Medical Sciences Postgraduate Program, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Fernanda Valdez-Palomares, Scientific Liaison Unit, Instituto Nacional de Medicina Genómica; Experimental Clinical Research Postgraduate Program, UNAM, Mexico City, Mexico
Laura Flores-Cisneros, Department of Clinical Research, Instituto Nacional de Cancerología (INCan); Medical Sciences Postgraduate Program, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Miriam Sánchez-López, Department of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Jaime H. Soto-Lugo, Department of Radiation Oncology, Christus Muguerza, Hospital del Parque, Chihuahua, Chih., Mexico
Denisse Castro-Eguiluz, Consejo Nacional de Ciencia y Tecnología (CONACyT) and Department of Clinical Research, INCan, Mexico City, Mexico

In the development of cervical cancer (CC), the immune response plays an essential role, from the elimination of human papillomavirus (HPV) infection to the response against the tumor. For optimal function of the immune response, various factors are required, one of the most important being an adequate nutrition. The complex interaction between nutrients and microbiota maintains the immune system in homeostasis and in case of infection, it provides the ability to fight against pathogen invasion, as occurs in HPV infection. The purpose of this article is to describe the role of diet, food, and specific nutrients in the immune response from the onset of infection to progression to precancerous lesions and CC, as well as the role of diet and nutrition during oncological treatment. The immunomodulatory role of microbiota is also discussed. A detailed analysis of the evidence leads us to recommend a nutritional pattern very similar to the Mediterranean diet or the prudent diet for an optimal immune response. Moreover, pre- and probiotics favorably modulate the microbiota and induce preventive and therapeutic effects against cancer.

Keywords: Immunonutrition. Diet. Human papillomavirus. Cervical cancer. Microbiota.

Full Article in PDF