ISSN: 0034-8376
eISSN: 2564-8896






The Sum of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scale and Their Correlation with eGFR Decline in Deceased Donor Kidney Recipients



Pablo Maggiani-Aguilera, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
Sergio Hernández-Estrada, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
José H. Cano-Cervantes, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
Jonathan S. Chávez-Iñiguez, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
Christian Pérez-Flores, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
Odette del C. Díaz-Avedaño, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
María C. Oseguera-Vizcaíno, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
Mayra Matías-Carmona, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
Daniel F. Ovando-Morga, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
María G. Ramírez-Ramírez, Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico
Guillermo Navarro-Blackaller, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
Marco A. Covarrubias-Velasco, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
José A. Torres-Mayorga, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
Benjamín Gómez-Navarro, University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico
Guillermo García-García, Renal Transplant Unit, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jal.; University of Guadalajara Health Sciences Center, Guadalajara, Jal., Mexico


Background: The impact of donor quality on post-kidney transplant survival may vary by candidate condition. Objective: Analyzing the combined use of the Kidney Donor Profile Index (KDPI) and the estimated post-transplant survival (EPTS) scale and their correlation with the estimated glomerular filtration rate (eGFR) decline in deceased-donor kidney recipients (DDKR). Methods: This was a retrospective, observational cohort study. We included DDKRs between 2015 and 2017 at a national third-level hospital. Results: We analyzed 68 DDKR. The mean age at transplant was 41 ± 14 years, 47 (69%) had sensitization events, 18 (26%) had delayed graft function, and 16 (23%) acute rejection. The graft survival at 12 and 36 months was 98.1% (95% CI 94-100) and 83.7% (95% CI 65-100), respectively. The Pearson correlation coefficient between the percentage reduction in the annual eGFR and the sum of EPTS and KDPI scales was r = 0.61, p < 0.001. The correlation coefficient between the percentage reduction in the annual eGFR and the EPTS and KDPI scales separately was r = 0.55, p < 0.001, and r = 0.53, p < 0.001, respectively. Conclusions: The sum of EPTS and KDPI scales can provide a better donor-recipient relationship and has a moderately positive correlation with the decrease in eGFR in DDKR.



Keywords: Kidney Donor Profile Index. Estimated post-transplant survival. Renal kidney graft survival. Deceased-donor kidney transplant. Estimate glomerular filtration rate. Graft loss.